4hc1
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hc1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hc1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 21:49, 25 December 2014
Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3
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