3mwt
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mwt RCSB], [http://www.ebi.ac.uk/pdbsum/3mwt PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mwt RCSB], [http://www.ebi.ac.uk/pdbsum/3mwt PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 13:39, 24 December 2014
Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+
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