We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1okx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 1okx |SIZE=350|CAPTION= <scene name='initialview01'>1okx</scene>, resolution 2.80&Aring;
|PDB= 1okx |SIZE=350|CAPTION= <scene name='initialview01'>1okx</scene>, resolution 2.80&Aring;
|SITE= <scene name='pdbsite=SC1:Scyptolin+A+Binding+Site+For+Chain+B'>SC1</scene>
|SITE= <scene name='pdbsite=SC1:Scyptolin+A+Binding+Site+For+Chain+B'>SC1</scene>
-
|LIGAND=
+
|LIGAND= <scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=CNT:N-METHYL-META-CHLORO-TYROSINE'>CNT</scene>, <scene name='pdbligand=SUJ:(2R,3R)-2-[(3S,6R)-3-AMINO-6-HYDROXY-2-OXOPIPERIDINYL]-3-HYDROXYBUTANOIC+ACID'>SUJ</scene>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36]
+
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1okx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okx OCA], [http://www.ebi.ac.uk/pdbsum/1okx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1okx RCSB]</span>
}}
}}
Line 34: Line 37:
[[Category: protease]]
[[Category: protease]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:12:16 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:46:48 2008''

Revision as of 19:46, 30 March 2008

Image:1okx.gif


PDB ID 1okx

Drag the structure with the mouse to rotate
, resolution 2.80Å
Sites:
Ligands: , ,
Activity: Pancreatic elastase, with EC number 3.4.21.36
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A


Overview

Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors.

About this Structure

1OKX is a Protein complex structure of sequences from Scytonema hofmanni and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266

Page seeded by OCA on Sun Mar 30 22:46:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1okx"
Personal tools