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4wyv
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wyv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wyv RCSB], [http://www.ebi.ac.uk/pdbsum/4wyv PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wyv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wyv RCSB], [http://www.ebi.ac.uk/pdbsum/4wyv PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The single-stranded DNA (ssDNA)/RNA binding protein translin was suggested to be involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation. Oligonucleotide binding surfaces map within a closed cavity of translin octameric barrels, raising the question as to how DNA/RNA gain access to this inner cavity, particularly given that, to date, none of the barrel structures reported hint to an entryway. Here, we argue against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. Additionally, we report that translin not only is confined to binding of ssDNA oligonucleotides, or single-stranded extensions of double-stranded DNA (dsDNA), but also can bind single-stranded sequences internally embedded in dsDNA molecules. | ||
| + | |||
| + | A Novel Open-Barrel Structure of Octameric Translin Reveals a Potential RNA Entryway.,Eliahoo E, Marx A, Manor H, Alian A J Mol Biol. 2014 Nov 26. pii: S0022-2836(14)00609-3. doi:, 10.1016/j.jmb.2014.11.013. PMID:25433126<ref>PMID:25433126</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:49, 17 December 2014
Crystal Structure of Human Translin in Open Conformation
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Categories: Alian, A | Dvir, H | Eliahoo, E | Barrel | Octomer | Open | Rna | Rna binding protein | Translin
