4cfg
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cfg RCSB], [http://www.ebi.ac.uk/pdbsum/4cfg PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN]] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: James, L]] | [[Category: James, L]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 06:49, 24 December 2014
Structure of the TRIM25 coiled-coil
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