1oo2
From Proteopedia
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|PDB= 1oo2 |SIZE=350|CAPTION= <scene name='initialview01'>1oo2</scene>, resolution 1.56Å | |PDB= 1oo2 |SIZE=350|CAPTION= <scene name='initialview01'>1oo2</scene>, resolution 1.56Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene> | + | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= TTR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8175 Sparus aurata]) | |GENE= TTR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8175 Sparus aurata]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1fhn|1FHN]], [[1f41|1F41]], [[1rlb|1RLB]], [[1qab|1qab]], [[1ie4|1IE4]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oo2 OCA], [http://www.ebi.ac.uk/pdbsum/1oo2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oo2 RCSB]</span> | ||
}} | }} | ||
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[[Category: Ramazzina, I.]] | [[Category: Ramazzina, I.]] | ||
[[Category: Zanotti, G.]] | [[Category: Zanotti, G.]] | ||
| - | [[Category: CD]] | ||
[[Category: retinol-binding protein]] | [[Category: retinol-binding protein]] | ||
[[Category: tetramer]] | [[Category: tetramer]] | ||
[[Category: transthyretin]] | [[Category: transthyretin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:47:59 2008'' |
Revision as of 19:48, 30 March 2008
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| , resolution 1.56Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | TTR (Sparus aurata) | ||||||
| Related: | 1FHN, 1F41, 1RLB, 1qab, 1IE4
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of transthyretin from Sparus aurata
Overview
The thyroid hormone binding protein transthyretin (TTR) forms a macromolecular complex with the retinol-specific carrier retinol binding protein (RBP) in the blood of higher vertebrates. Piscine TTR is shown here to exhibit high binding affinity for L-thyroxine and negligible affinity for RBP. The 1.56 A resolution X-ray structure of sea bream TTR, compared with that of human TTR, reveals a high degree of conservation of the thyroid hormone binding sites. In contrast, some amino acid differences in discrete regions of sea bream TTR appear to be responsible for the lack of protein-protein recognition, providing evidence for the crucial role played by a limited number of residues in the interaction between RBP and TTR. Overall, this study makes it possible to draw conclusions on evolutionary relationships for RBPs and TTRs of phylogenetically distant vertebrates.
About this Structure
1OO2 is a Single protein structure of sequence from Sparus aurata. Full crystallographic information is available from OCA.
Reference
Distinctive binding and structural properties of piscine transthyretin., Folli C, Pasquato N, Ramazzina I, Battistutta R, Zanotti G, Berni R, FEBS Lett. 2003 Dec 4;555(2):279-84. PMID:14644428
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