Thioredoxin

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Line 33: Line 33:
**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) – human<br />
**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) – human<br />
-
**[[3kd0]] - hTrx (mutant)+CdCl2<br />
 
-
**[[1cqg]], [[1cqh]] - hTrx (mutant)+Ref-1 peptide – NMR<br />
 
-
**[[1mdi]], [[1mdj]], [[1mdk]] - hTrx + Target peptide of NFKB – NMR<br />
 
**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
**[[4oo5]] - hTrx S-nitroso (mutant)<br />
**[[4oo5]] - hTrx S-nitroso (mutant)<br />
Line 42: Line 39:
**[[3hyp]] - BfrxI fragment (mutant)<br />
**[[3hyp]] - BfrxI fragment (mutant)<br />
**[[3hz4]] – Trx – ''Methanosarcina mazei''<br />
**[[3hz4]] – Trx – ''Methanosarcina mazei''<br />
-
**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
 
**[[3die]] – SaTrx (mutant) – ''Staphylococcus aureus''<br />
**[[3die]] – SaTrx (mutant) – ''Staphylococcus aureus''<br />
**[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br />
**[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br />
**[[2gzy]], [[2gzz]] – BsTrx – NMR<br />
**[[2gzy]], [[2gzz]] – BsTrx – NMR<br />
-
**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
 
**[[2h6x]], [[2trx]], [[1srx]] – EcTrx<br />
**[[2h6x]], [[2trx]], [[1srx]] – EcTrx<br />
**[[1xoa]], [[1xob]] – EcTrx - NMR<br />
**[[1xoa]], [[1xob]] – EcTrx - NMR<br />
**[[1m7t]] – hTrx/EcTrx chimera - NMR<br />
**[[1m7t]] – hTrx/EcTrx chimera - NMR<br />
-
**[[3dxb]] – hTrx+Puf60 C-terminal<br />
 
**[[3emx]] – Trx – ''Aeropyrum pernix''<br />
**[[3emx]] – Trx – ''Aeropyrum pernix''<br />
**[[2vim]] – Trx – ''Fasciola hepatica''<br />
**[[2vim]] – Trx – ''Fasciola hepatica''<br />
-
**[[2yzu]], [[2cvk]], [[1v98]] – TtTrx – ''Thermus thermophilus''<br />
+
**[[2yzu]], [[2cvk]], [[1v98]], [[4tn8]] – TtTrx – ''Thermus thermophilus''<br />
**[[2lst]] – TtTrx - NMR<br />
**[[2lst]] – TtTrx - NMR<br />
**[[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br />
**[[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br />
Line 65: Line 59:
**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
 +
**[[2mmn]], [[2mmo]] - PfTrx - NMR<br />
**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
**[[1gl8]] – Trx – spinach - NMR<br />
**[[1gl8]] – Trx – spinach - NMR<br />
Line 74: Line 69:
**[[2xbq]], [[2xc2]] – SmTrx (mutant)<br />
**[[2xbq]], [[2xc2]] – SmTrx (mutant)<br />
**[[4i8b]] - Trx – ''Schistosoma japonicum''<br />
**[[4i8b]] - Trx – ''Schistosoma japonicum''<br />
-
**[[3zzx]], [[4aj8]], [[4aj7]], [[4aj6]] – Trx – ''Litopenaeus vannamei''<br />
+
**[[3zzx]], [[4aj8]], [[4aj7]], [[4aj6]], [[4v2l]], [[4v2m]], [[4v2n]] – Trx – ''Litopenaeus vannamei''<br />
**[[4fyu]] – Trx – ''Wuchereria bancrofti''<br />
**[[4fyu]] – Trx – ''Wuchereria bancrofti''<br />
**[[4knd]] – Trx – ''Anaeromyxobacter dehalogenans''<br />
**[[4knd]] – Trx – ''Anaeromyxobacter dehalogenans''<br />
Line 84: Line 79:
**[[2yj7]], [[2yn1]], [[2yoi]], [[2ypm]], [[3ziv]], [[4ba7]] – ancestral Trx – synthetic<br />
**[[2yj7]], [[2yn1]], [[2yoi]], [[2ypm]], [[3ziv]], [[4ba7]] – ancestral Trx – synthetic<br />
**[[4pob]] – Trx – ''Mycobacterium abscessus''<br />
**[[4pob]] – Trx – ''Mycobacterium abscessus''<br />
 +
**[[2ynx]], [[4ulx]] – Trx – Last Archaea Common Ancestor<br />
 +
**[[4cw9]] - Trx (mutant) – ''Entamoeba histolytica''<br />
 +
**[[4wxt]] - Trx – ''Mycobacterium avium''<br />
 +
 +
*Thioredoxin complexes
 +
 +
**[[3kd0]] - hTrx (mutant)+CdCl2<br />
 +
**[[4pok]], [[4pol]], [[4pom]] - hTrx (mutant)+ thioethanesulfonate<br />
 +
**[[4puf]] - hTrx (mutant)+ E3 ubiquitin-protein ligase<br />
 +
**[[1cqg]], [[1cqh]] - hTrx (mutant)+Ref-1 peptide – NMR<br />
 +
**[[1mdi]], [[1mdj]], [[1mdk]] - hTrx + Target peptide of NFKB – NMR<br />
 +
**[[3dxb]] – hTrx+Puf60 C-terminal<br />
 +
**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
 +
**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
*Thioredoxin 1
*Thioredoxin 1
Line 119: Line 128:
**[[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br />
**[[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br />
**[[1thx]] – Trx-2 – Anabaena<br />
**[[1thx]] – Trx-2 – Anabaena<br />
-
**[[3ul3]] – PfTrx-2
+
**[[3ul3]], [[4o32]] – PfTrx-2
*Thioredoxin 3
*Thioredoxin 3
-
**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3
+
**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3<br />
 +
**[[4xhm]] – Trx-3 – ''Archaeoglobus fulgidus''<br />
*Thioredoxin C
*Thioredoxin C

Revision as of 10:21, 18 June 2015

Image:1ert.png
Crystal Structure of Thioredoxin 1ert

Template:STRUCTURE 3kd0










Thioredoxin (Trx) is an enzyme which facilitates the reduction of proteins by cysteine thiol-disulfide exchange. They contain a CXXC motif.

  • Trx-1 is a mammalian cellular protein.
  • Trx-2 is mitochondria-specific.

In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes.

3D Structures of Thioredoxin

Updated on 18-June-2015

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