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Thymidine kinase
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**[[3f0t]], [[1of1]], [[4jby]], [[4jbx]], [[4ivr]], [[4ivq]], [[4ivp]] – HsvTK residues 45-376 + thymine derivative <BR /> | **[[3f0t]], [[1of1]], [[4jby]], [[4jbx]], [[4ivr]], [[4ivq]], [[4ivp]] – HsvTK residues 45-376 + thymine derivative <BR /> | ||
**[[3rdp]] - HsvTK residues 45-376 + pyrimidine derivative<br /> | **[[3rdp]] - HsvTK residues 45-376 + pyrimidine derivative<br /> | ||
| + | **[[4oql]], [[4oqm]], [[4oqn]], [[4oqx]] - HsvTK residues 45-376 + uridine derivative<br /> | ||
**[[1qhi]], [[1ki3]], [[1ki5]], [[1ki2]], [[1ki4]] - HsvTK + inhibitor<BR /> | **[[1qhi]], [[1ki3]], [[1ki5]], [[1ki2]], [[1ki4]] - HsvTK + inhibitor<BR /> | ||
**[[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR /> | **[[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR /> | ||
**[[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR /> | **[[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR /> | ||
**[[1p6x]] – EhvTK + THM – Equine Herpes virus 4<BR /> | **[[1p6x]] – EhvTK + THM – Equine Herpes virus 4<BR /> | ||
| + | **[[4uxh]], [[4uxi]], [[4uxj]] – TK + thymidine derivative – ''Leishmania major''<br /> | ||
**[[1p72]] - EhvTK + THM + ADP<BR /> | **[[1p72]] - EhvTK + THM + ADP<BR /> | ||
**[[2qqe]] – TmTK + THM<BR /> | **[[2qqe]] – TmTK + THM<BR /> | ||
Revision as of 11:01, 18 June 2015
Thymidine kinase (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the coversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. TK1 is cell cycle-dependent while TK2 is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK.
3D Structures of thymidine kinase
Updated on 18-June-2015
