Transposase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Transposases''' bind to the ends of a transposon and catalyze its movement to another part of the genome by a cut-and-paste mechanism. Transposase contains a DDE motif in its active site enabling it to coordinate the binding of divalent metal ions. The metal ions affect transposase reactivity. | + | '''Transposases''' bind to the ends of a transposon and catalyze its movement to another part of the genome by a cut-and-paste mechanism. Transposase contains a DDE motif in its active site enabling it to coordinate the binding of divalent metal ions. The metal ions affect transposase reactivity. <br /> |
| - | '''Mu transposase''' (MuA) is essential for integration, replication-transposition and excision of bacteriophage Mu DNA into multiple sites of bacterial genome. Mu transposition occurs within the transposome which is a protein-DNA complex which includes 4 subunits of MuA. | + | *'''Mu transposase''' (MuA) is essential for integration, replication-transposition and excision of bacteriophage Mu DNA into multiple sites of bacterial genome. Mu transposition occurs within the transposome which is a protein-DNA complex which includes 4 subunits of MuA.<br /> |
| + | *'''Hermes transposase''' is a fly protein.<br /> | ||
| + | * '''Dra2 transposase''' is a ''Deinococcus radiodurans'' protein<br /> | ||
| + | *'''Tn5 transposase''' active site contains the DDE motif which catalyzes the movement of the transposon<br /> | ||
| + | *'''Mos1 transposase''' mediates the movement of Mos1 transposon<br /> | ||
| + | *'''Tc3 transposase''' mediates the movement of Tc3 transposon in ''C. elegans''<br /> | ||
== Disease == | == Disease == | ||
Revision as of 11:04, 15 December 2014
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3D structures of transposase
Updated on 15-December-2014
