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TRNA methyltransferase
From Proteopedia
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<StructureSection load='1uak' size='350' side='right' caption='Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry [[1uak]])' scene=''> | <StructureSection load='1uak' size='350' side='right' caption='Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry [[1uak]])' scene=''> | ||
| - | + | == Function == | |
| - | '''tRNA methyltransferase''' (Trm) methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH). S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction. | + | '''tRNA methyltransferase''' (Trm) methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH)<ref>PMID:25626150</ref>. S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction. |
For details on Trm to N2 of guanine 6 see [[TRNA:m2G6 methyltransferase TrmN/Trm14]]. | For details on Trm to N2 of guanine 6 see [[TRNA:m2G6 methyltransferase TrmN/Trm14]]. | ||
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| + | == Structural highlights == | ||
| + | Trm active site is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[3bt7]] – yTrm + RNA<br /> | **[[3bt7]] – yTrm + RNA<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:14, 25 September 2016
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3D structures of tRNA methyltransferase
Updated on 25-September-2016
References
- ↑ Swinehart WE, Jackman JE. Diversity in mechanism and function of tRNA methyltransferases. RNA Biol. 2015;12(4):398-411. doi: 10.1080/15476286.2015.1008358. PMID:25626150 doi:http://dx.doi.org/10.1080/15476286.2015.1008358
- ↑ Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK. Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376 doi:10.1093/emboj/cdg269
