Trypsin inhibitor

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== Function ==
== Function ==
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'''Trypsin inhibitors''' (TI) inhibit the enzymatic activity of serine proteases and thus have nutritional effect. TI natural sources are bovine, ovomucoid, soybean, lima bean and other plants. See also [[Basic Pancreatic Trypsin Inhibitor]].
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'''Trypsin inhibitors''' (TI) inhibit the enzymatic activity of serine proteases and thus have nutritional effect. TI natural sources are bovine, ovomucoid, soybean, lima bean and other plants. '''Kunitz-type TI''' are found in legume seeds. '''Bowman-Birk-type TI''' are found in legume and cereal grains seeds.See also [[Basic Pancreatic Trypsin Inhibitor]].
== Disease ==
== Disease ==
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*Trypsin inhibitor
*Trypsin inhibitor
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**[[1cti]], [[2cti]], [[3cti]] – sTI - squash - NMR<br />
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**[[1cti]], [[2cti]], [[3cti]], [[1ha9]], [[1hym]], [[1mit]], [[1tin]], [[2it7]], [[2it8]] – sTI - squash - NMR<br />
**[[1lu0]], [[2v1v]] – sTI (mutant)<br />
**[[1lu0]], [[2v1v]] – sTI (mutant)<br />
**[[1jbl]], [[1jbn]], [[1o8y]], [[1o8z]] – suTI – sunflower - NMR<br />
**[[1jbl]], [[1jbn]], [[1o8y]], [[1o8z]] – suTI – sunflower - NMR<br />
**[[1t9e]] – suTI (mutant) - NMR<br />
**[[1t9e]] – suTI (mutant) - NMR<br />
**[[2ab9]] – suTI precursor - NMR<br />
**[[2ab9]] – suTI precursor - NMR<br />
 +
**[[4ttk]] – suTI <br />
 +
**[[1ata]], [[1atb]], [[1atd]], [[1ate]] – asTI – ascaris - NMR<br />
 +
**[[1dwm]] – TI – flax - NMR<br />
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**[[1hx2]] – TI – toad - NMR<br />
 +
**[[1ib9]], [[2eti]], [[2let]], [[2ljs]], [[2po8]] – cuTI – cucumber - NMR<br />
 +
**[[1w7z]] – cuTI II – cucumber <br />
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**[[1iw4]] – TI – Halocynthia roretzi - NMR<br />
 +
**[[1qh2]], [[1tih]] – TI – tobacco - NMR<br />
 +
**[[1tie]] – TI – erythrina<br />
 +
**[[1vbw]] – bpTI A – balsam pear<br />
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**[[2aih]] – TI – lentil - NMR<br />
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**[[2lqx]] – bwTI – buckwheat - NMR<br />
 +
**[[3iir]], [[3zc8]], [[3zc9]] – TI – ''Murraya koenigii''<br />
 +
**[[4j2k]] – etTI - earpod tree<br />
*Trypsin inhibitor complex with protease
*Trypsin inhibitor complex with protease
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**[[1ppe]], [[2sta]] – sTI + trypsin<br />
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**[[1ppe]], [[2sta]], [[2btc]], [[2stb]] – sTI + trypsin<br />
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**[[1sfi]], [[4hgc]] – suTI + trypsin <br />
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**[[1sfi]], [[4hgc]], [[4abj]] – suTI + trypsin <br />
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**[[1f2s]], [[1mct]] – bpTI A + trypsin <br />
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**[[2cmy]] – TI + trypsin - veronica<br />
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**[[3myw]] – TI + trypsin – ''Vigna radiata''<br />
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**[[3rdz]] – bwTI + trypsin <br />
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**[[4j2y]] – etTI + trypsin <br />
 +
**[[4gux]] – cuTI II + trypsin <br />
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**[[1h9h]], [[1h9i]] – cuTI II (mutant) + trypsin <br />
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**[[4aoq]], [[4aor]] – TI 3 + trypsin - spinach<br />
**[[3p8f]] – suTI + membrane-type serine protease<br />
**[[3p8f]] – suTI + membrane-type serine protease<br />
**[[4k1e]], [[4kel]] – suTI (mutant) + kallikrein-4<br />
**[[4k1e]], [[4kel]] – suTI (mutant) + kallikrein-4<br />
**[[4k8y]] – suTI + kallikrein-4<br />
**[[4k8y]] – suTI + kallikrein-4<br />
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 +
*Kunitz type trypsin inhibitor
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 +
**[[1avu]], [[1ba7]] – sbTI – soybean<br />
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**[[1r8n]] – TI – ''Delonix regia''<br />
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**[[1r8o]] – TI – ''Copaifera langsdorffii''<br />
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**[[1shp]] – TI – sea anemone - NMR<br />
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**[[4an6]] – taTI - tamarind <br />
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**[[1avw]], [[1avx]] – sbTI + trypsin <br />
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**[[4an7]] – taTI + trypsin <br />
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 +
*Bowman-Birk type trypsin inhibitor
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 +
**[[1bbi]], [[2bbi]] – sbTI – NMR<br />
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**[[1k9b]] – sbTI <br />
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**[[1c2a]], [[2fj8]] – baTI – barley<br />
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**[[2r33]] – CoTI - cowpea<br />
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**[[1tx6]] – baTI + trypsin <br />
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**[[2qn5]] – TI + trypsin - rice<br />
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**[[4u2w]] – TI + trypsin - frog<br />
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**[[2g81]] – CoTI + trypsin <br />
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**[[3ru4]] – CoTI + trypsin + chymotrypsinogen<br />
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**[[1d6r]], [[1g9i]] – sbTI + trypsinogen<br />
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}}
}}
== References ==
== References ==

Revision as of 09:51, 22 June 2015

Squash seed trypsin inhibitor structure (wheat) complex with trypsin (magenta) and Ca+2 ion (green) (PDB code 2sta).

Drag the structure with the mouse to rotate

3D Structures of trypsin inhibitor

Updated on 22-June-2015

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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