Ubiquitin

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Line 40: Line 40:
**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br />
**[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]], [[2kox]], [[2ld9]], [[2k25]] – hUBB – NMR - human<br />
-
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]] - hUBB<br />
+
**[[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]], [[3ons]], [[4wzp]] - hUBB<br />
-
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]] - hUBB (mutant)<br />
+
**[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]], [[4hk2]], [[4hjk]], [[4pij]], [[4pih]], [[4pig]] - hUBB (mutant)<br />
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
**[[1c3t]], [[1ud7]], [[2mi8]], [[2rsu]], [[2ru6]] - hUBB (mutant) - NMR<br />
**[[2m0x]] - hUBB - engineered – NMR<br />
**[[2m0x]] - hUBB - engineered – NMR<br />
Line 47: Line 47:
**[[1e0q]] - hUBB N-terminal (mutant) – NMR<br />
**[[1e0q]] - hUBB N-terminal (mutant) – NMR<br />
**[[3q3f]] – hUBB/ribonuclease<br />
**[[3q3f]] – hUBB/ribonuclease<br />
 +
**[[4zpz]] – hPolyUBB-B (mutant)<br />
 +
**[[5af4]], [[4xyz]] – hPolyUBB-C <br />
 +
**[[5af5]] – hPolyUBB-C (mutant)<br />
**[[2k39]] – UBB – ''Xenopus laevis'' – NMR<br />
**[[2k39]] – UBB – ''Xenopus laevis'' – NMR<br />
**[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br />
**[[2jwz]], [[1zw7]] – yUBB (mutant) – yeast<br />
Line 71: Line 74:
**[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br />
**[[3m3j]], [[1aar]], [[3aui]] – bDiUBB <br />
**[[2bgf]] – hDiUBB – chemical relaxation<br />
**[[2bgf]] – hDiUBB – chemical relaxation<br />
 +
**[[4s22]] – bDiUBB <br />
* Ubiquitin dimer bound to protein
* Ubiquitin dimer bound to protein
Line 87: Line 91:
**[[4fjv]] – hDiUBB + UBB thiolesterase <br />
**[[4fjv]] – hDiUBB + UBB thiolesterase <br />
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
**[[4bos]] – hDiUBB + UBB thiolesterase + OTUD2<br />
 +
**[[4s1z]] – hDiUBB + ZranB1<br />
* Ubiquitin trimer
* Ubiquitin trimer
Line 123: Line 128:
**[[3phd]] – hPolyUBB+histone deacetylase 6<br />
**[[3phd]] – hPolyUBB+histone deacetylase 6<br />
**[[3znh]] – hPolyUBB-B + UBB thioesterase<br />
**[[3znh]] – hPolyUBB-B + UBB thioesterase<br />
 +
**[[4uf6]] – hPolyUBB-B + UCH-L5 + NF-κ-b-related protein<br />
**[[3znz]] – hPolyUBB-C + otulin<br />
**[[3znz]] – hPolyUBB-C + otulin<br />
**[[4jqw]] – hPolyUBB-C + NOD1 CARD<br />
**[[4jqw]] – hPolyUBB-C + NOD1 CARD<br />
Line 140: Line 146:
**[[3rul]] – hUBB + dalvancin<br />
**[[3rul]] – hUBB + dalvancin<br />
**[[3vfk]] – hUBB + monodechloro-teicoplanin <br />
**[[3vfk]] – hUBB + monodechloro-teicoplanin <br />
-
**[[4ium]] – hUBB+ papain-like protease<br />
+
**[[4ium]], [[4wur]], [[4mm3]] – hUBB+ papain-like protease<br />
**[[2lz6]], [[2mcn]] – hUBB + CD2-associated protein<br />
**[[2lz6]], [[2mcn]] – hUBB + CD2-associated protein<br />
**[[2mbh]] – hUBB + Kreuppel-like factor<br />
**[[2mbh]] – hUBB + Kreuppel-like factor<br />
Line 146: Line 152:
**[[3vht]] – hUBB + GFP<br />
**[[3vht]] – hUBB + GFP<br />
**[[4jio]] – hUBB + yBRO1<br />
**[[4jio]] – hUBB + yBRO1<br />
 +
**[[5af6]] – hUBB + TRABID<br />
 +
**[[4un2]] – hUBB + Dsk2 peptide<br />
 +
**[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br />
 +
**[[5af6]] – hUBB + TRABID<br />
 +
**[[4un2]] – hUBB + Dsk2 peptide<br />
 +
**[[4msq]], [[4msm]] – hUBB + AMSH-like protease<br />
**[[4m0w]] – bUBB + replicase polyprotein<br />
**[[4m0w]] – bUBB + replicase polyprotein<br />
**[[1uzx]] – bUBB+VPS23 UEV<br />
**[[1uzx]] – bUBB+VPS23 UEV<br />
Line 163: Line 175:
**[[1wr1]] – yUBB+DSK2P UBA<br />
**[[1wr1]] – yUBB+DSK2P UBA<br />
**[[1otr]] – yUBB+CUE2<br />
**[[1otr]] – yUBB+CUE2<br />
-
**[[2l00]] – yUBB + Zfand5
+
**[[2l00]] – yUBB + Zfand5<br />
 +
**[[4q5h]], [[4q5e]] – yUBB + UBB conjugating enzyme E2 + OspG<br />
 +
**[[4nql]] – mUBB + AMSH-like protease<br />
* Ubiquitin + ions
* Ubiquitin + ions

Revision as of 09:03, 24 June 2015

Image:1d3z.png
NMR Structure of Ubiquitin, 1d3z

Template:STRUCTURE 3k9p












Ubiquitin (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome. For details see

Additional Resources

See: Ubiquitin Structure & Function for additional information.

3D Structures of Ubiquitin

Updated on 24-June-2015

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