UDP-galactose 4-epimerase
From Proteopedia
(Difference between revisions)
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<StructureSection load='1nah' size='350' side='right' caption='Structure of UDP-galactose 4 epimerase complex with NAD, UDP (stick model), PEG and Na+1 (purple) ions (PDB entry [[1nah]])' scene=''> | <StructureSection load='1nah' size='350' side='right' caption='Structure of UDP-galactose 4 epimerase complex with NAD, UDP (stick model), PEG and Na+1 (purple) ions (PDB entry [[1nah]])' scene=''> | ||
| + | == Function == | ||
| + | '''UDP-galactose 4-epimerase''' (GalE) reversibly converts UDP-galactose to UDP-glucose. GalE catalyzes the last step in galactose metabolism<ref>PMID:12534808</ref>. GalE uses NAD+ as a cofactor. | ||
| - | + | == Disease == | |
| + | Mutations in GalE are the cause of galactosemia which is autosomal recessive disorder<ref>PMID:16301867</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[3aw9]] - PcGalE (mutant) + NAD + UDP-galactopyranose <br /> | **[[3aw9]] - PcGalE (mutant) + NAD + UDP-galactopyranose <br /> | ||
}} | }} | ||
| + | ==References== | ||
| + | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:11, 5 December 2016
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3D structures of UDP-galactose 4 epimerase
Updated on 05-December-2016
References
- ↑ Mozzi F, Savoy de Giori G, Font de Valdez G. UDP-galactose 4-epimerase: a key enzyme in exopolysaccharide formation by Lactobacillus casei CRL 87 in controlled pH batch cultures. J Appl Microbiol. 2003;94(2):175-83. PMID:12534808
- ↑ Park HD, Park KU, Kim JQ, Shin CH, Yang SW, Lee DH, Song YH, Song J. The molecular basis of UDP-galactose-4-epimerase (GALE) deficiency galactosemia in Korean patients. Genet Med. 2005 Nov-Dec;7(9):646-9. PMID:16301867 doi:10.109701.gim.0000194023.27802.2d
