4wsq
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wsq RCSB], [http://www.ebi.ac.uk/pdbsum/4wsq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wsq RCSB], [http://www.ebi.ac.uk/pdbsum/4wsq PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AAK1_HUMAN AAK1_HUMAN]] Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.<ref>PMID:12952931</ref> <ref>PMID:17494869</ref> <ref>PMID:18657069</ref> <ref>PMID:21464124</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 21:17, 25 December 2014
Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with small molecule inhibitor
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Categories: Non-specific serine/threonine protein kinase | Abdul, K | Arrowsmith, C H | Bountra, C | Delft, F Von | Edwards, A M | Elkins, J M | Gileadi, O | Knapp, S | Krojer, T | Structural genomic | Sorrell, F J | Williams, E | Catalytic domain | Kinase | Protein binding | Protein kinase | Protein kinase inhibitor | Small-molecule | Transferase
