1owx

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|ACTIVITY=
|ACTIVITY=
|GENE= SSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= SSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1owx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1owx OCA], [http://www.ebi.ac.uk/pdbsum/1owx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1owx RCSB]</span>
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[[Category: rrm]]
[[Category: rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:32 2008''

Revision as of 19:51, 30 March 2008

Image:1owx.jpg


PDB ID 1owx

Drag the structure with the mouse to rotate
Gene: SSB (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Solution structure of the C-terminal RRM of human La (La225-334)


Overview

The La protein is an important component of ribonucleoprotein complexes that acts mainly as an RNA chaperone to facilitate correct processing and maturation of RNA polymerase III transcripts, but can also stimulate translation initiation. We report here the structure of the C-terminal domain of human La, which comprises an atypical RNA recognition motif (La225-334) and a long unstructured C-terminal tail. The central beta sheet of La225-334 reveals novel features: the putative RNA binding surface is formed by a five-stranded beta sheet and, strikingly, is largely obscured by a long C-terminal alpha helix that encompasses a recently identified nuclear retention element. Contrary to previous observations, we find that the La protein does not contain a dimerization domain.

About this Structure

1OWX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element., Jacks A, Babon J, Kelly G, Manolaridis I, Cary PD, Curry S, Conte MR, Structure. 2003 Jul;11(7):833-43. PMID:12842046

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