1p9x

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|PDB= 1p9x |SIZE=350|CAPTION= <scene name='initialview01'>1p9x</scene>, resolution 3.40&Aring;
|PDB= 1p9x |SIZE=350|CAPTION= <scene name='initialview01'>1p9x</scene>, resolution 3.40&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene>
+
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1nkw|1NKW]], [[1njm|1NJM]], [[1njn|1NJN]], [[1jzy|1JZY]], [[1jzx|1JZX]], [[1ond|1OND]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9x OCA], [http://www.ebi.ac.uk/pdbsum/1p9x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p9x RCSB]</span>
}}
}}
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[[Category: Yonath, A.]]
[[Category: Yonath, A.]]
[[Category: Zarivach, R.]]
[[Category: Zarivach, R.]]
-
[[Category: TEL]]
 
[[Category: antibiotic]]
[[Category: antibiotic]]
[[Category: blockage]]
[[Category: blockage]]
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[[Category: trna]]
[[Category: trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:56 2008''

Revision as of 19:56, 30 March 2008

Image:1p9x.gif


PDB ID 1p9x

Drag the structure with the mouse to rotate
, resolution 3.40Å
Ligands: , , , ,
Related: 1NKW, 1NJM, 1NJN, 1JZY, 1JZX, 1OND


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC


Overview

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

About this Structure

1P9X is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804

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