1pm4
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= ypma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 Yersinia pseudotuberculosis]) | |GENE= ypma ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 Yersinia pseudotuberculosis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm4 OCA], [http://www.ebi.ac.uk/pdbsum/1pm4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pm4 RCSB]</span> | ||
}} | }} | ||
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[[Category: jelly roll fold]] | [[Category: jelly roll fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:29 2008'' |
Revision as of 20:01, 30 March 2008
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| , resolution 1.755Å | |||||||
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| Gene: | ypma (Yersinia pseudotuberculosis) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Yersinia pseudotuberculosis-derived mitogen (YPM)
Overview
Superantigens are a class of microbial proteins with the ability to excessively activate T cells by binding to the T cell receptor. The staphylococcal and streptococcal superantigens are closely related in structure and possess an N-terminal domain that resembles an OB fold and a C-terminal domain similar to a beta-grasp fold. Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other proteins. We have determined the crystal and solution structures of YPMa, which show that the protein has a jelly-roll fold. The closest structural neighbors to YPMa are viral capsid proteins and members of the tumor necrosis factor superfamily. In the crystal structure, YPMa packs as a trimer, another feature shared with viral capsid proteins and TNF superfamily proteins. However, in solution YPMa behaves as a monomer, and any functional relevance of the trimer observed in the crystals is yet to be established.
About this Structure
1PM4 is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.
Reference
Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold., Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA, Structure. 2004 Jan;12(1):145-56. PMID:14725774
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