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1pnn

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|PDB= 1pnn |SIZE=350|CAPTION= <scene name='initialview01'>1pnn</scene>, resolution 2.5&Aring;
|PDB= 1pnn |SIZE=350|CAPTION= <scene name='initialview01'>1pnn</scene>, resolution 2.5&Aring;
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|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=IPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-5-IODOURACIL'>IPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pnn OCA], [http://www.ebi.ac.uk/pdbsum/1pnn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pnn RCSB]</span>
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[[Category: triplex watson-crick hoogsteen]]
[[Category: triplex watson-crick hoogsteen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:26:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:02:03 2008''

Revision as of 20:02, 30 March 2008

Image:1pnn.gif


PDB ID 1pnn

Drag the structure with the mouse to rotate
, resolution 2.5Å
Ligands: , , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA


Overview

The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.

About this Structure

1PNN is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381

Page seeded by OCA on Sun Mar 30 23:02:03 2008

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