2m5v

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m5v RCSB], [http://www.ebi.ac.uk/pdbsum/2m5v PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m5v RCSB], [http://www.ebi.ac.uk/pdbsum/2m5v PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NAL10_HUMAN NAL10_HUMAN]] Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.<ref>PMID:15096476</ref> <ref>PMID:20393137</ref> <ref>PMID:22672233</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 16:52, 25 December 2014

Three-dimensional structure of human NLRP10/PYNOD pyrin domain

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