2lu3
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu3 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). | ||
==See Also== | ==See Also== | ||
Revision as of 13:34, 25 December 2014
Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase
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