2kzy
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [http://www.ebi.ac.uk/pdbsum/2kzy PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [http://www.ebi.ac.uk/pdbsum/2kzy PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B5DF11_RAT B5DF11_RAT]] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 00:23, 25 December 2014
Solution NMR structure of the ZNF216 A20 zinc finger
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