1q3a
From Proteopedia
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|PDB= 1q3a |SIZE=350|CAPTION= <scene name='initialview01'>1q3a</scene>, resolution 2.10Å | |PDB= 1q3a |SIZE=350|CAPTION= <scene name='initialview01'>1q3a</scene>, resolution 2.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22] </span> |
|GENE= MMP10 OR STMY2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= MMP10 OR STMY2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1g49|1G49]], [[1bqo|1BQO]], [[1d5j|1D5J]], [[1d8f|1D8F]], [[1uea|1UEA]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3a OCA], [http://www.ebi.ac.uk/pdbsum/1q3a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q3a RCSB]</span> | ||
}} | }} | ||
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[[Category: Mangani, S.]] | [[Category: Mangani, S.]] | ||
[[Category: Terni, B.]] | [[Category: Terni, B.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: NGH]] | ||
| - | [[Category: ZN]] | ||
[[Category: hydroxamic acid]] | [[Category: hydroxamic acid]] | ||
[[Category: inhibitor]] | [[Category: inhibitor]] | ||
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[[Category: stromelysin-2]] | [[Category: stromelysin-2]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:13 2008'' |
Revision as of 20:08, 30 March 2008
| |||||||
| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | MMP10 OR STMY2 (Homo sapiens) | ||||||
| Activity: | Stromelysin 2, with EC number 3.4.24.22 | ||||||
| Related: | 1G49, 1BQO, 1D5J, 1D8F, 1UEA
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the catalytic domain of human matrix metalloproteinase 10
Overview
The catalytic domain of matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 A resolution. The availability of this structure allowed us to critically examine the small differences existing between the catalytic domains of MMP-3 and MMP-10, which show the highest sequence identity among all MMPs. Furthermore, the binding mode of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH), which is one of the most known commercial inhibitors of MMPs, is described for the first time.
About this Structure
1Q3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human matrix metalloproteinase 10., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, J Mol Biol. 2004 Feb 20;336(3):707-16. PMID:15095982
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