This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3g0u
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4== | ==Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4== | ||
<StructureSection load='3g0u' size='340' side='right' caption='[[3g0u]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3g0u' size='340' side='right' caption='[[3g0u]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G0U FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MDY:(2Z)-N-(3-CHLORO-2-METHOXYBIPHENYL-4-YL)-2-CYANO-3-HYDROXYBUT-2-ENAMIDE'>MDY</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MDY:(2Z)-N-(3-CHLORO-2-METHOXYBIPHENYL-4-YL)-2-CYANO-3-HYDROXYBUT-2-ENAMIDE'>MDY</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f1q|3f1q]], [[3fj6|3fj6]], [[3fjl|3fjl]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f1q|3f1q]], [[3fj6|3fj6]], [[3fjl|3fjl]]</td></tr> | ||
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g0u RCSB], [http://www.ebi.ac.uk/pdbsum/3g0u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g0u OCA], [http://pdbe.org/3g0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g0u RCSB], [http://www.ebi.ac.uk/pdbsum/3g0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g0u ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| Line 20: | Line 21: | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g0u ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 30: | Line 31: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3g0u" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 37: | Line 39: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | + | ||
[[Category: Davis, M]] | [[Category: Davis, M]] | ||
[[Category: Fishwick, C W.G]] | [[Category: Fishwick, C W.G]] | ||
Revision as of 21:07, 4 August 2016
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4
| |||||||||||
