1q5f
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= PilS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=601 Salmonella typhi]) | |GENE= PilS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=601 Salmonella typhi]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5f OCA], [http://www.ebi.ac.uk/pdbsum/1q5f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q5f RCSB]</span> | ||
}} | }} | ||
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[[Category: type ivb pilin]] | [[Category: type ivb pilin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:09:03 2008'' |
Revision as of 20:09, 30 March 2008
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| Gene: | PilS (Salmonella typhi) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of Type IVb pilin (PilS) from Salmonella typhi
Overview
The structure of the N-terminal-truncated Type IVb structural pilin (t-PilS) from Salmonella typhi was determined by NMR. Although topologically similar to the recently determined x-ray structure of pilin from Vibrio cholerae toxin-coregulated pilus, the only Type IVb pilin with known structure, t-PilS contains many distinct structural features. The protein contains an extra pair of beta-strands in the N-terminal alphabeta loop that align with the major beta-strands to form a continuous 7-stranded antiparallel beta-sheet. The C-terminal disulfide-bonded region of t-PilS is only half the length of that of toxin-coregulated pilus pilin. A model of S. typhi pilus has been proposed and mutagenesis studies suggested that residues on both the alphabeta loop and the C-terminal disulfide-bonded region of PilS might be involved in binding specificity of the pilus. This model structure reveals an exposed surface between adjacent subunits of PilS that could be a potential binding site for the cystic fibrosis transmembrane conductance regulator.
About this Structure
1Q5F is a Single protein structure of sequence from Salmonella typhi. Full crystallographic information is available from OCA.
Reference
NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:15159389
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