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3kbl
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kbl RCSB], [http://www.ebi.ac.uk/pdbsum/3kbl PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kbl RCSB], [http://www.ebi.ac.uk/pdbsum/3kbl PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLD1_CAEEL GLD1_CAEEL]] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 19:42, 24 December 2014
Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans N169A mutant at 2.28 A resolution
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Categories: Caenorhabditis elegans | Beuck, C | Carmel, A B | Columbus, L | Kerkow, D E | Stanfield, R L | Szymczyna, B R | Williamson, J R | Developmental protein | Differentiation | Gld-1 | Helix-turn-helix motif | Hydrophobic homodimer interface | Meiosis | N169a mutant | Oogenesis | Perpendicular stacking of protomer | Protein binding | Qua1 homodimerization domain | Rna-binding | Translation regulation
