1qa9

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qa9 OCA], [http://www.ebi.ac.uk/pdbsum/1qa9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qa9 RCSB]</span>
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[[Category: ig-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:10:57 2008''

Revision as of 20:10, 30 March 2008

Image:1qa9.jpg


PDB ID 1qa9

Drag the structure with the mouse to rotate
, resolution 3.2Å
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of a Heterophilic Adhesion Complex Between the Human CD2 and CD58(LFA-3) Counter-Receptors


Overview

Interaction between CD2 and its counterreceptor, CD58 (LFA-3), on opposing cells optimizes immune recognition, facilitating contacts between helper T lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. Here, we report the crystal structure of the heterophilic adhesion complex between the amino-terminal domains of human CD2 and CD58. A strikingly asymmetric, orthogonal, face-to-face interaction involving the major beta sheets of the respective immunoglobulin-like domains with poor shape complementarity is revealed. In the virtual absence of hydrophobic forces, interdigitating charged amino acid side chains form hydrogen bonds and salt links at the interface (approximately 1200 A2), imparting a high degree of specificity albeit with low affinity (K(D) of approximately microM). These features explain CD2-CD58 dynamic binding, offering insights into interactions of related immunoglobulin superfamily receptors.

About this Structure

1QA9 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors., Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL, Cell. 1999 Jun 11;97(6):791-803. PMID:10380930

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