1qhv
From Proteopedia
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|PDB= 1qhv |SIZE=350|CAPTION= <scene name='initialview01'>1qhv</scene>, resolution 1.51Å | |PDB= 1qhv |SIZE=350|CAPTION= <scene name='initialview01'>1qhv</scene>, resolution 1.51Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2]) | |GENE= LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qhv OCA], [http://www.ebi.ac.uk/pdbsum/1qhv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qhv RCSB]</span> | ||
}} | }} | ||
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[[Category: Louis, N.]] | [[Category: Louis, N.]] | ||
[[Category: Raaij, M J.Van.]] | [[Category: Raaij, M J.Van.]] | ||
| - | [[Category: SO4]] | ||
[[Category: extra-ordinary stability]] | [[Category: extra-ordinary stability]] | ||
[[Category: receptor binding]] | [[Category: receptor binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:48 2008'' |
Revision as of 20:13, 30 March 2008
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| , resolution 1.51Å | |||||||
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| Ligands: | |||||||
| Gene: | LOCUS AD2H2 (Human adenovirus 2) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD
Overview
Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
About this Structure
1QHV is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.
Reference
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512
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