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3ki7
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki7 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | ||
==See Also== | ==See Also== | ||
*[[Exotoxin|Exotoxin]] | *[[Exotoxin|Exotoxin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:38, 24 December 2014
Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I
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