3l4h
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l4h RCSB], [http://www.ebi.ac.uk/pdbsum/3l4h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l4h RCSB], [http://www.ebi.ac.uk/pdbsum/3l4h PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HECW1_HUMAN HECW1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 04:12, 25 December 2014
Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1
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