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3k49
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k49 RCSB], [http://www.ebi.ac.uk/pdbsum/3k49 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k49 RCSB], [http://www.ebi.ac.uk/pdbsum/3k49 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PUF3_YEAST PUF3_YEAST]] RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology.<ref>PMID:11101532</ref> <ref>PMID:15337848</ref> <ref>PMID:16355254</ref> <ref>PMID:16244132</ref> <ref>PMID:17210948</ref> <ref>PMID:18523582</ref> <ref>PMID:18094119</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 13:40, 24 December 2014
Puf3 RNA binding domain bound to Cox17 RNA 3' UTR recognition sequence site B
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