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1qo8
From Proteopedia
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|PDB= 1qo8 |SIZE=350|CAPTION= <scene name='initialview01'>1qo8</scene>, resolution 2.15Å | |PDB= 1qo8 |SIZE=350|CAPTION= <scene name='initialview01'>1qo8</scene>, resolution 2.15Å | ||
|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Resdiue+A601'>AC1</scene>, <scene name='pdbsite=AC2:Hem+Binding+Site+For+Resdiue+A602'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Resdiue+A603'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Resdiue+A604'>AC4</scene>, <scene name='pdbsite=AC5:Fad+Binding+Site+For+Resdiue+A605'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Resdiue+D601'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Resdiue+D602'>AC7</scene>, <scene name='pdbsite=AC8:Hem+Binding+Site+For+Residue+D603'>AC8</scene>, <scene name='pdbsite=AC9:Hem+Binding+Site+For+Residue+D604'>AC9</scene> and <scene name='pdbsite=BC1:Fad+Binding+Site+For+Residue+D605'>BC1</scene> | |SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Resdiue+A601'>AC1</scene>, <scene name='pdbsite=AC2:Hem+Binding+Site+For+Resdiue+A602'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Resdiue+A603'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Resdiue+A604'>AC4</scene>, <scene name='pdbsite=AC5:Fad+Binding+Site+For+Resdiue+A605'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Resdiue+D601'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Resdiue+D602'>AC7</scene>, <scene name='pdbsite=AC8:Hem+Binding+Site+For+Residue+D603'>AC8</scene>, <scene name='pdbsite=AC9:Hem+Binding+Site+For+Residue+D604'>AC9</scene> and <scene name='pdbsite=BC1:Fad+Binding+Site+For+Residue+D605'>BC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qo8 OCA], [http://www.ebi.ac.uk/pdbsum/1qo8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qo8 RCSB]</span> | ||
}} | }} | ||
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[[Category: Hemmings, A M.]] | [[Category: Hemmings, A M.]] | ||
[[Category: Richardson, D J.]] | [[Category: Richardson, D J.]] | ||
| - | [[Category: FAD]] | ||
| - | [[Category: HEM]] | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:37 2008'' |
Revision as of 20:16, 30 March 2008
| |||||||
| , resolution 2.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , and | ||||||
| Ligands: | , | ||||||
| Activity: | Succinate dehydrogenase, with EC number 1.3.99.1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE
Overview
Fumarate reductases and succinate dehydrogenases play central roles in the metabolism of eukaryotic and prokaryotic cells. A recent medium resolution structure of the Escherichia coli fumarate reductase (Frd) has revealed the overall organization of the membrane-bound complex. Here we present the first high resolution X-ray crystal structure of a water-soluble bacterial fumarate reductase in an open conformation. This structure reveals a mobile domain that modulates substrate access to the active site and provides new insights into the mechanism of this widespread and important family of FAD-containing respiratory proteins.
About this Structure
1QO8 is a Single protein structure of sequence from Shewanella frigidimarina. Full crystallographic information is available from OCA.
Reference
Open conformation of a flavocytochrome c3 fumarate reductase., Bamford V, Dobbin PS, Richardson DJ, Hemmings AM, Nat Struct Biol. 1999 Dec;6(12):1104-7. PMID:10581549
Page seeded by OCA on Sun Mar 30 23:16:37 2008
