1qqh
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqh OCA], [http://www.ebi.ac.uk/pdbsum/1qqh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qqh RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QQH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1QQH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQH OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of the human papillomavirus type 18 E2 activation domain., Harris SF, Botchan MR, Science. 1999 Jun 4;284(5420):1673-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10356398 10356398] | Crystal structure of the human papillomavirus type 18 E2 activation domain., Harris SF, Botchan MR, Science. 1999 Jun 4;284(5420):1673-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10356398 10356398] | ||
| - | [[Category: Human papillomavirus type | + | [[Category: Human papillomavirus type 18]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Botchan, M R.]] | [[Category: Botchan, M R.]] | ||
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[[Category: cashew/kidney shape]] | [[Category: cashew/kidney shape]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:17:34 2008'' |
Revision as of 20:17, 30 March 2008
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| , resolution 2.10Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
2.1 A CRYSTAL STRUCTURE OF THE HUMAN PAPILLOMAVIRUS TYPE 18 E2 ACTIVATION DOMAIN
Overview
The papillomavirus E2 protein regulates viral transcription and DNA replication through interactions with cellular and viral proteins. The amino-terminal activation domain, which represents a protein class whose structural themes are poorly understood, contains key residues that mediate these functional contacts. The crystal structure of a protease-resistant core of the human papillomavirus type 18 E2 activation domain reveals a novel fold creating a cashew-shaped form with a glutamine-rich alpha helix packed against a beta-sheet framework. The protein surface shows extensive overlap of determinants for replication and transcription. The structure broadens the concept of activators to include proteins with potentially malleable, but certainly ordered, structures.
About this Structure
1QQH is a Single protein structure of sequence from Human papillomavirus type 18. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human papillomavirus type 18 E2 activation domain., Harris SF, Botchan MR, Science. 1999 Jun 4;284(5420):1673-7. PMID:10356398
Page seeded by OCA on Sun Mar 30 23:17:34 2008
