3qsv
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsv RCSB], [http://www.ebi.ac.uk/pdbsum/3qsv PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsv RCSB], [http://www.ebi.ac.uk/pdbsum/3qsv PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SMAD4_MOUSE SMAD4_MOUSE]] Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:10, 25 December 2014
Structural basis for DNA recognition by constitutive Smad4 MH1 dimers
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