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3v6a
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6a RCSB], [http://www.ebi.ac.uk/pdbsum/3v6a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v6a RCSB], [http://www.ebi.ac.uk/pdbsum/3v6a PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 21:29, 25 December 2014
Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules
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