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1rau
From Proteopedia
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|PDB= 1rau |SIZE=350|CAPTION= <scene name='initialview01'>1rau</scene> | |PDB= 1rau |SIZE=350|CAPTION= <scene name='initialview01'>1rau</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rau OCA], [http://www.ebi.ac.uk/pdbsum/1rau PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rau RCSB]</span> | ||
}} | }} | ||
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[[Category: tetraplex]] | [[Category: tetraplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:25:33 2008'' |
Revision as of 20:25, 30 March 2008
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES
Overview
A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.
About this Structure
1RAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:1382577
Page seeded by OCA on Sun Mar 30 23:25:33 2008
Categories: Protein complex | Cheong, C. | Moore, P B. | Nmr | Rna | Tetraplex
