1rau

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|PDB= 1rau |SIZE=350|CAPTION= <scene name='initialview01'>1rau</scene>
|PDB= 1rau |SIZE=350|CAPTION= <scene name='initialview01'>1rau</scene>
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rau OCA], [http://www.ebi.ac.uk/pdbsum/1rau PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rau RCSB]</span>
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[[Category: tetraplex]]
[[Category: tetraplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:49:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:25:33 2008''

Revision as of 20:25, 30 March 2008

Image:1rau.gif


PDB ID 1rau

Drag the structure with the mouse to rotate
Ligands: ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES


Overview

A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.

About this Structure

1RAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures., Cheong C, Moore PB, Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:1382577

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