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4g6j
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g6j RCSB], [http://www.ebi.ac.uk/pdbsum/4g6j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g6j RCSB], [http://www.ebi.ac.uk/pdbsum/4g6j PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 14:31, 24 December 2014
Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab
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