1rxl

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|ACTIVITY=
|ACTIVITY=
|GENE= afae3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
|GENE= afae3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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|RELATEDENTRY=[[1sdd|1SDD]], [[1ut2|1UT2]], [[1ut1|1UT1]], [[1usq|1USQ]], [[1usz|1USZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxl OCA], [http://www.ebi.ac.uk/pdbsum/1rxl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rxl RCSB]</span>
}}
}}
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[[Category: upec]]
[[Category: upec]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:57:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:22 2008''

Revision as of 20:34, 30 March 2008

Image:1rxl.gif


PDB ID 1rxl

Drag the structure with the mouse to rotate
Gene: afae3 (Escherichia coli)
Related: 1SDD, 1UT2, 1UT1, 1USQ, 1USZ


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Solution structure of the engineered protein Afae-dsc


Overview

Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers.

About this Structure

1RXL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:15327779

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