1s0u
From Proteopedia
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|PDB= 1s0u |SIZE=350|CAPTION= <scene name='initialview01'>1s0u</scene>, resolution 2.4Å | |PDB= 1s0u |SIZE=350|CAPTION= <scene name='initialview01'>1s0u</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= EIF2G, MJ1261 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]) | |GENE= EIF2G, MJ1261 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s0u OCA], [http://www.ebi.ac.uk/pdbsum/1s0u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s0u RCSB]</span> | ||
}} | }} | ||
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[[Category: Dever, T E.]] | [[Category: Dever, T E.]] | ||
[[Category: Roll-Mecak, A.]] | [[Category: Roll-Mecak, A.]] | ||
| - | [[Category: ZN]] | ||
[[Category: ef-1a]] | [[Category: ef-1a]] | ||
[[Category: eif2]] | [[Category: eif2]] | ||
| Line 34: | Line 36: | ||
[[Category: trna]] | [[Category: trna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:35:52 2008'' |
Revision as of 20:35, 30 March 2008
| |||||||
| , resolution 2.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | EIF2G, MJ1261 (Methanocaldococcus jannaschii) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
eIF2gamma apo
Overview
The x-ray structure of the gamma-subunit of the heterotrimeric translation initiation factor eIF2 has been determined to 2.4-A resolution. eIF2 is a GTPase that delivers the initiator Met-tRNA to the P site on the small ribosomal subunit during a rate-limiting initiation step in translation. The structure of eIF2gamma closely resembles that of EF1A.GTP, consisting of an N-terminal G domain followed by two beta-barrels arranged in a closed configuration with domain II packed against the G domain in the vicinity of the Switch regions. The G domain of eIF2gamma has an unusual zinc ribbon motif, not previously found in other GTPases. Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of eIF2gamma that bind the alpha-subunit and Met-tRNA(i)(Met), respectively. These structural, biochemical, and genetic results provide new insights into eIF2 ternary complex assembly.
About this Structure
1S0U is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding., Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK, J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. PMID:14688270
Page seeded by OCA on Sun Mar 30 23:35:52 2008
