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4i0e
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i0e RCSB], [http://www.ebi.ac.uk/pdbsum/4i0e PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i0e RCSB], [http://www.ebi.ac.uk/pdbsum/4i0e PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 22:20, 24 December 2014
Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
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