1s6a
From Proteopedia
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|PDB= 1s6a |SIZE=350|CAPTION= <scene name='initialview01'>1s6a</scene>, resolution 1.69Å | |PDB= 1s6a |SIZE=350|CAPTION= <scene name='initialview01'>1s6a</scene>, resolution 1.69Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GLBN, SLR2097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1143 Synechocystis sp.]) | |GENE= GLBN, SLR2097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1143 Synechocystis sp.]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1s69|1S69]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s6a OCA], [http://www.ebi.ac.uk/pdbsum/1s6a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s6a RCSB]</span> | ||
}} | }} | ||
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[[Category: III, J T.Trent.]] | [[Category: III, J T.Trent.]] | ||
[[Category: Kundu, S.]] | [[Category: Kundu, S.]] | ||
| - | [[Category: AZI]] | ||
| - | [[Category: FLC]] | ||
| - | [[Category: HEM]] | ||
[[Category: 2 on 2 helical fold]] | [[Category: 2 on 2 helical fold]] | ||
[[Category: cyanobacteria]] | [[Category: cyanobacteria]] | ||
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[[Category: truncated]] | [[Category: truncated]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:38:03 2008'' |
Revision as of 20:38, 30 March 2008
| |||||||
| , resolution 1.69Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | GLBN, SLR2097 (Synechocystis sp.) | ||||||
| Related: | 1S69
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand
Overview
The crystal structures of cyanide and azide-bound forms of the truncated hemoglobin from Synechocystis are presented at 1.8 angstroms resolution. A comparison with the structure of the endogenously liganded protein reveals a conformational shift unprecedented in hemoglobins, and provides the first picture of a hexacoordinate hemoglobin in both the bis-histidyl and the exogenously coordinated states. The structural changes between the different conformations are confined to two regions of the protein; the B helix, and the E helix, including the EF loop. A molecular "hinge" controlling movement of the E helix is observed in the EF loop, which is composed of three principal structural elements: Arg64, the heme-d-propionate, and a three-residue extension of the F helix. Additional features of the structural transition between the two protein conformations are discussed as they relate to the complex ligand-binding behavior observed in hexacoordinate hemoglobins, and the potential physiological function of this class of proteins.
About this Structure
1S6A is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.
Reference
Crystallographic analysis of synechocystis cyanoglobin reveals the structural changes accompanying ligand binding in a hexacoordinate hemoglobin., Trent JT 3rd, Kundu S, Hoy JA, Hargrove MS, J Mol Biol. 2004 Aug 20;341(4):1097-108. PMID:15289104
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