1sbs
From Proteopedia
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|PDB= 1sbs |SIZE=350|CAPTION= <scene name='initialview01'>1sbs</scene>, resolution 2.0Å | |PDB= 1sbs |SIZE=350|CAPTION= <scene name='initialview01'>1sbs</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbs OCA], [http://www.ebi.ac.uk/pdbsum/1sbs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sbs RCSB]</span> | ||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: Isaacs, N W.]] | [[Category: Isaacs, N W.]] | ||
[[Category: Schielen, W J.G.]] | [[Category: Schielen, W J.G.]] | ||
| - | [[Category: SO4]] | ||
[[Category: fab-fragment]] | [[Category: fab-fragment]] | ||
[[Category: monoclonal antibody]] | [[Category: monoclonal antibody]] | ||
[[Category: reproduction]] | [[Category: reproduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:39:56 2008'' |
Revision as of 20:39, 30 March 2008
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| , resolution 2.0Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF AN ANTI-HCG FAB
Overview
3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 944 ordered water molecules and one sulfate ion. A comparison of the complementarity-determining regions of the Fab3A2 with those from the Protein Data Bank following the canonical structure method reveals a canonical main chain conformation. This antibody belongs to the canonical structure class (combination of canonical conformations of the complementarity determining loops) that shows a preference for haptens and not for peptides. However, the shape of the surface of the antigen binding loops resembles that of an anti-peptide antibody.
About this Structure
1SBS is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution., Fotinou C, Beauchamp J, Emsley P, deHaan A, Schielen WJ, Bos E, Isaacs NW, J Biol Chem. 1998 Aug 28;273(35):22515-8. PMID:9712877
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