2bgd
From Proteopedia
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[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
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Revision as of 15:32, 5 November 2007
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Overview
Using structure-based design, a new class of inhibitors of protein, tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the, 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
About this Structure
2BGD is a Single protein structure of sequence from Homo sapiens with CL, PO4, NA and T1D as ligands. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Mon Nov 5 17:37:25 2007
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Black, E. | Breed, J. | Breeze, A.L. | Embrey, K. | Garcia, R. | Gero, T.W. | Godfrey, L. | Kenny, P.W. | Minshull, C.A. | Morley, A.D. | Pannifer, A.D. | Read, J. | Rees, A. | Russell, D.J. | Toader, D. | Tucker, J. | CL | NA | PO4 | T1D | 1 | 1-dioxide template | 2 | 5-thiadiazolidin-3-one-1 | Hydrolase | Protein tyrosine phosphatase
