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4llr

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Revision as of 03:05, 5 August 2016

Tryparedoxin peroxidase (TXNPX) from trypanosoma cruzi in the reduced state

Structural highlights

4llr is a 10 chain structure with sequence from Trycr. This structure supersedes the now removed PDB entry 1uul. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	Tryp (TRYCR)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Tryparedoxin peroxidase from Trypanosoma cruzi (TcTXNPx) belongs to the family of typical 2-Cys peroxiredoxins. These enzymes function as antioxidants through their peroxidase and peroxynitrite reductase activities. In T. cruzi, as in all trypanosomatids, this enzyme is the final electron acceptor of a unique system for detoxifying hydroperoxides, constituting a relevant target for drug design. We have determined the crystal structure of TcTXPNx in the reduced active state. The structure comprises 10 subunits in the asymmetric unit, associated to form a decamer of toroidal shape obeying 52 (D5) point group symmetry. We have analyzed the structure of TcTXNPx by comparing it with other structures of typical 2-Cys peroxiredoxins in both redox states, and have identified key residues in the structural rearrangement taking place in the enzymatic cycle. This is the first report of the structure of an active peroxiredoxin that has peroxidase and peroxynitrite reductase activity, and it is noteworthy that it is from a human parasite. This knowledge is of interest for further understanding peroxide metabolism in these parasites, and in the design of new trypanosomatidal drugs against Chagas disease.

Crystal structure of the tryparedoxin peroxidase from the human parasite Trypanosoma cruzi.,Pineyro MD, Pizarro JC, Lema F, Pritsch O, Cayota A, Bentley GA, Robello C J Struct Biol. 2005 Apr;150(1):11-22. PMID:15797726^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pineyro MD, Pizarro JC, Lema F, Pritsch O, Cayota A, Bentley GA, Robello C. Crystal structure of the tryparedoxin peroxidase from the human parasite Trypanosoma cruzi. J Struct Biol. 2005 Apr;150(1):11-22. PMID:15797726 doi:10.1016/j.jsb.2004.12.005

1 Structural highlights
2 Publication Abstract from PubMed
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4llr"

@@ Line 1: / Line 1: @@
 ==Tryparedoxin peroxidase (TXNPX) from trypanosoma cruzi in the reduced state==
 <StructureSection load='4llr' size='340' side='right' caption='[[4llr]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4llr]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uul 1uul]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4llr]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uul 1uul]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLR FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tryp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tryp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llr RCSB], [http://www.ebi.ac.uk/pdbsum/4llr PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llr OCA], [http://pdbe.org/4llr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4llr RCSB], [http://www.ebi.ac.uk/pdbsum/4llr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4llr ProSAT]</span></td></tr>
 </table>
 <div style="background-color:#fffaf0;">
@@ Line 14: / Line 15: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4llr" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Trypanosoma cruzi]]
+[[Category: Trycr]]
 [[Category: Bentley, G A]]
 [[Category: Cayota, A]]

4llr

From Proteopedia

Revision as of 03:05, 5 August 2016

Tryparedoxin peroxidase (TXNPX) from trypanosoma cruzi in the reduced state

Structural highlights

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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