4kuc
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kuc RCSB], [http://www.ebi.ac.uk/pdbsum/4kuc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kuc RCSB], [http://www.ebi.ac.uk/pdbsum/4kuc PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | ||
==See Also== | ==See Also== | ||
Revision as of 18:50, 24 December 2014
Crystal structure of ricin-A chain in complex with the antibody 6C2
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