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4jzc
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jzc RCSB], [http://www.ebi.ac.uk/pdbsum/4jzc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jzc RCSB], [http://www.ebi.ac.uk/pdbsum/4jzc PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ANGP2_HUMAN ANGP2_HUMAN]] Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.<ref>PMID:9204896</ref> <ref>PMID:15284220</ref> <ref>PMID:19116766</ref> <ref>PMID:19223473</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 13:46, 24 December 2014
Angiopoietin-2 fibrinogen domain TAG mutant
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