4lv5
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv5 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 15:47, 25 December 2014
Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI
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