1sjm
From Proteopedia
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|PDB= 1sjm |SIZE=350|CAPTION= <scene name='initialview01'>1sjm</scene>, resolution 1.40Å | |PDB= 1sjm |SIZE=350|CAPTION= <scene name='initialview01'>1sjm</scene>, resolution 1.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NO2:NITRITE+ION'>NO2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Nitrite_reductase_(NO-forming) Nitrite reductase (NO-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.2.1 1.7.2.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrite_reductase_(NO-forming) Nitrite reductase (NO-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.2.1 1.7.2.1] </span> |
|GENE= NIRK, NIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511 Alcaligenes faecalis]) | |GENE= NIRK, NIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511 Alcaligenes faecalis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1j9q|1J9Q]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjm OCA], [http://www.ebi.ac.uk/pdbsum/1sjm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sjm RCSB]</span> | ||
}} | }} | ||
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[[Category: Rosell, F I.]] | [[Category: Rosell, F I.]] | ||
[[Category: Tocheva, E I.]] | [[Category: Tocheva, E I.]] | ||
| - | [[Category: ACT]] | ||
| - | [[Category: CU]] | ||
| - | [[Category: NO2]] | ||
| - | [[Category: TRS]] | ||
[[Category: copper]] | [[Category: copper]] | ||
[[Category: nitrite]] | [[Category: nitrite]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:56 2008'' |
Revision as of 20:42, 30 March 2008
| |||||||
| , resolution 1.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | NIRK, NIR (Alcaligenes faecalis) | ||||||
| Activity: | Nitrite reductase (NO-forming), with EC number 1.7.2.1 | ||||||
| Related: | 1J9Q
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Nitrite bound copper containing nitrite reductase
Overview
A copper-nitrosyl intermediate forms during the catalytic cycle of nitrite reductase, the enzyme that mediates the committed step in bacterial denitrification. The crystal structure of a type 2 copper-nitrosyl complex of nitrite reductase reveals an unprecedented side-on binding mode in which the nitrogen and oxygen atoms are nearly equidistant from the copper cofactor. Comparison of this structure with a refined nitrite-bound crystal structure explains how coordination can change between copper-oxygen and copper-nitrogen during catalysis. The side-on copper-nitrosyl in nitrite reductase expands the possibilities for nitric oxide interactions in copper proteins such as superoxide dismutase and prions.
About this Structure
1SJM is a Single protein structure of sequence from Alcaligenes faecalis. Full crystallographic information is available from OCA.
Reference
Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:15131305
Page seeded by OCA on Sun Mar 30 23:42:56 2008
