4nm8
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4nm8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4nm8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 14:17, 25 December 2014
Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin
| |||||||||||
