1so9
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= CTAG, R00908, SMC00012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382 Sinorhizobium meliloti]) | |GENE= CTAG, R00908, SMC00012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382 Sinorhizobium meliloti]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1sp0|1SP0]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1so9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1so9 OCA], [http://www.ebi.ac.uk/pdbsum/1so9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1so9 RCSB]</span> | ||
}} | }} | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:44:46 2008'' |
Revision as of 20:44, 30 March 2008
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| Gene: | CTAG, R00908, SMC00012 (Sinorhizobium meliloti) | ||||||
| Related: | 1SP0
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of apoCox11, 30 structures
Overview
Cytochrome c oxidase assembly process involves many accessory proteins including Cox11, which is a copper-binding protein required for Cu incorporation into the Cu(B) site of cytochrome c oxidase. In a genome wide search, a number of Cox11 homologs are found in all of the eukaryotes with complete genomes and in several Gram-negative bacteria. All of them possess a highly homologous soluble domain and contain an N-terminal fragment that anchors the protein to the membrane. An anchor-free construct of 164 amino acids was obtained from Sinorhizobium meliloti, and the first structure of this class of proteins is reported here. The apoform has an immunoglobulin-like fold with a novel type of beta-strand organization. The copper binding motif composed of two highly conserved cysteines is located on one side of the beta-barrel structure. The apoprotein is monomeric in the presence of dithiothreitol, whereas it dimerizes in the absence of the reductant. When copper(I) binds, NMR and extended x-ray absorption fine structure (EXAFS) data indicate a dimeric protein state with two thiolates bridging two copper(I) ions. The present results advance the knowledge on the poorly understood molecular aspects of cytochrome c oxidase assembly.
About this Structure
1SO9 is a Single protein structure of sequence from Sinorhizobium meliloti. Full crystallographic information is available from OCA.
Reference
Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase., Banci L, Bertini I, Cantini F, Ciofi-Baffoni S, Gonnelli L, Mangani S, J Biol Chem. 2004 Aug 13;279(33):34833-9. Epub 2004 Jun 4. PMID:15181013
Page seeded by OCA on Sun Mar 30 23:44:46 2008
Categories: Single protein | Sinorhizobium meliloti | Banci, L. | Bertini, I. | Cantini, F. | Ciofi-Baffoni, S. | Gonnelli, L. | Mangani, S. | SPINE, Structural Proteomics in Europe. | Copper protein | Cytochrome c oxidase assembly | Immunoglobulin-like fold | Spine | Structural genomic | Structural proteomics in europe
