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1svz
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1jp5|1JP5]], [[1cl2|1Cl2]], [[1n4x|1N4X]], [[1mf2|1MF2]], [[2hrp|2HRP]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1svz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svz OCA], [http://www.ebi.ac.uk/pdbsum/1svz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1svz RCSB]</span> | ||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: Rezacova, P.]] | [[Category: Rezacova, P.]] | ||
[[Category: Sedlacek, J.]] | [[Category: Sedlacek, J.]] | ||
| - | [[Category: antibody-antigen complex | + | [[Category: antibody-antigen complex]] |
| + | [[Category: hiv inhibiting antibody]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:41 2008'' |
Revision as of 20:47, 30 March 2008
| |||||||
| , resolution 1.89Å | |||||||
|---|---|---|---|---|---|---|---|
| Related: | 1JP5, 1Cl2, 1N4X, 1MF2, 2HRP
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease
Overview
The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
About this Structure
1SVZ is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587
Page seeded by OCA on Sun Mar 30 23:47:41 2008
